Images See all
Animal-free Recombinant Human Oncostatin M is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 30 kDa. This higher molecular mass is due to glycosylation and is not seen in the E. coli expressed form of this cytokine (22kDa). Glycosylation contributes to stability in cell growth media and other applications. This product is produced in a human cell expression system with serum-free, chemically defined media.
Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).