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Animal-free Recombinant Human Thrombopoietin is expressed from human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 80 to 85 kDa. This cytokine is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications. C- terminal domain glycosylation is thought to be important for the secretion of Thrombopoietin from cells and for survival of Thrombopoietin in the circulation.
Thrombopoietin (TPO) is a primary regulator of megakaryocyte development and platelet production in mammals. Human Thrombopoietin constitutively circulates and maintains thrombopoiesis through interaction with its cognate receptor, myeloproliferative leukemia protein(MPL). Thrombopoietin also plays an important role in the maintenance and regulation of hematopoietic stem cells (HSCs).